Ribosomal Protein L23 Activates p53 by Inhibiting MDM2 Function in Response to Ribosomal Perturbation but Not to Translation Inhibition
نویسندگان
چکیده
منابع مشابه
Inhibition of HDM2 and activation of p53 by ribosomal protein L23.
The importance of coordinating cell growth with proliferation has been recognized for a long time. The molecular basis of this relationship, however, is poorly understood. Here we show that the ribosomal protein L23 interacts with HDM2. The interaction involves the central acidic domain of HDM2 and an N-terminal domain of L23. L23 and L11, another HDM2-interacting ribosomal protein, can simulta...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2004
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.24.17.7654-7668.2004